By Vice President for Research Lisa Cassis
When you look back at a 45-year career, there are a multitude of moments that stand out. For Allan Butterfield, Professor of Biological Chemistry in the University of Kentucky College of Arts & Sciences, his signature discovery grew from just such a Eureka moment on the sidewalk on campus.
“I was walking back from Sanders-Brown Center on Aging to the Chemistry Building — two or three blocks — I kept asking myself, why are there so many proteins that are known to be altered in Alzheimer's disease? Why isn’t there just one?” Butterfield said, “And it occurred to me, ‘Oh, what if there is a free radical in the brain that is hitting all these different proteins and different lipids and causing them to be defective